Creatine raises serum creatinine and lowers calculated eGFR without changing actual filtration. What 26 randomised trials found when they measured clearance with a tracer instead of estimating it.

Which gut bacteria convert ellagitannins to urolithin A, the three metabotypes and what they really mean, whether your status can change, and why nobody has measured any of it in kidney disease.

Reported adverse events from every randomised trial of urolithin A, the laboratory data nobody has published, the renal clearance question, drug interactions, and the 2026 case series describing urolithin A inside kidney stones.

Both of the largest human trials of urolithin A missed their primary endpoints. Every human trial to date, what each measured, and which claims survive the data.